- PhD, University of California, Irvine
Dr. Christopher Wiley is a Scientist II in the Basic Biology of Aging Team at the HNRCA. His research focuses on the role of metabolism and nutrition in cellular senescence. Senescence is a form of cellular aging in which a cell adopts a permanent proliferative arrest, coupled to the secretion of a mélange of inflammatory cytokines, chemokines, growth factors, proteases, and oxylipins. Models that allow selective elimination of senescent cells, or “senolysis”, show that senescent cells drive multiple degenerative pathologies. Dr. Wiley discovered a distinct form of senescence driven by mitochondrial dysfunction, known as mitochondrial dysfunction-associated senescence (MiDAS). He also discovered that senescent cells promote clotting and coagulation and identified altered lipid metabolism as a major property of senescent cells. Dr. Wiley recently identified a specific lipid, dihomo-15d-PGJ2, as the first known biomarker of senolysis.