Study #3195 Resistance Exercise Response - The BRIO Study

Purpose of this study: The purpose of this study is to examine how cellular processes related to aging may influence a person's response to exercise, including changes in muscle size, muscle strength, and their body's response to dietary carbohydrates

Target population:
Men and women aged 65 years or older, defined as sedentary and at risk for mobility disability

Inclusion criteria:

• 65 years or older
• Not currently engaged in regular physical activity (sedentary)
• Have some difficulty with daily activities
• Willing to be randomized into either the health education or exercise intervention program
• Willing to be transported or transport themselves to the HNRCA for intervention and assessments

Major exclusions:

• Currently using an anti-coagulant or anti-platelet therapy
• Lidocaine allergy
• Acute or terminal illness
• Type 1 diabetes
• Type 2 diabetes with insulin use

Length of study:

• 24 weeks (~6 months)

Residency:

• None

Time commitment/number of visits:

• 24 weeks - 2 baseline visits, 2 follow-up visits:
  • Education group: 1 visit per week (24 intervention visits); 28 visits total
  • Exercise group: 3 visits per week (72 intervention visits); 76 visits total

Can I work?

• Yes, but if subjects employed by Tufts University qualify to participate in the study, they cannot participate as subjects during hours in which they are being compensated by Tufts.

Payment:

Participants could receive up to $1,000 for completing the entire study. This will be broken up by visit as follows:

• Baseline visit 1: $125
• Baseline visit 2: $125
• Follow up visit 1 (visit 3): $125
• Follow up visit 2 (visit 4): $125
• Study completion: $500