Study #3195 Resistance Exercise Response - The BRIO Study

Men and women aged 65 years or older, defined as sedentary and at risk for mobility disability

The purpose of this study is to examine how cellular processes related to aging may influence a person's response to exercise, including changes in muscle size, muscle strength, and their body's response to dietary carbohydrates

Inclusion criteria:

• 65 years or older
• Not currently engaged in regular physical activity (sedentary)
• Have some difficulty with daily activities
• Willing to be randomized into either the health education or exercise intervention program
• Willing to be transported or transport themselves to the HNRCA for intervention and assessments

Major exclusions:

• Currently using an anti-coagulant or anti-platelet therapy
• Lidocaine allergy
• Acute or terminal illness
• Type 1 diabetes
• Type 2 diabetes with insulin use

Length of study:

• 24 weeks (~6 months)

Residency:

• None

Payment:

Participants could receive up to $1,000 for completing the entire study. This will be broken up by visit as follows:

• Baseline visit 1: $125
• Baseline visit 2: $125
• Follow up visit 1 (visit 3): $125
• Follow up visit 2 (visit 4): $125
• Study completion: $500 

Number of visits:

• 24 weeks - 2 baseline visits, 2 follow-up visits:
  • Education group: 1 visit per week (24 intervention visits); 28 visits total

  • Exercise group: 3 visits per week (72 intervention visits); 76 visits total

    Can I work? Yes, but if subjects employed by Tufts University qualify to participate in the study, they cannot participate as subjects during hours in which they are being compensated by Tufts.