Research/Areas of Interest
The role of metabolism in aging at the cellular level
Education
- PhD, University of California, Irvine
Biography
Dr. Christopher Wiley, PhD, is a Scientist II in the Metabolism & Basic Biology of Aging directive at the HNRCA. His research focuses on the role of metabolism and nutrition in cellular senescence and other cell outcomes associated with aging.
Dr. Wiley's contributions to the field of aging research include discovery of a distinct form of senescence driven by mitochondrial dysfunction, known as mitochondrial dysfunction-associated senescence (MiDAS). He also discovered that senescent cells promote clotting and coagulation and identified altered fatty acid metabolism as a major property of senescent cells, including description of a lipid secretome associated with senescence. This also included discovery of specific lipid, dihomo-15d-PGJ2, as the first known biomarker of senolysis.
Dr. Wiley is a member of the American Aging Association, the international Cellular Senescence Association and the Gerontological Society of America.