Obesity Metabolism

Mission
The Obesity and Metabolism Laboratory is focused on understanding the mechanisms that cause obesity and obesity-related complications. By understanding the basis of obesity we are interested in developing strategies to ameliorate obesity and its complications.

Lab Objectives
Our research centers on understanding the molecular, cellular, and systemic basis of obesity and its complications. We have focused a significant amount of our research on the proteins that regulate the cellular trafficking, storage and metabolism of fatty acids and lipid metabolism. An important goal of our laboratory is to delineate mechanisms that will provide mechanistic insights into pathways that will ameliorate obesity and/or its metabolic and inflammatory complications.  In our studies we use cells, tissues, mouse knockout models, and human tissues and in certain situations clinical studies.   Our initial studies focused on white and brown adipocyte metabolism and its systemic consequences, our work has now branched has branched into studies liver, intestine, and skeletal muscle metabolism, the microbiome, and regulation of brain metabolism relevant to our studies on metabolic pathways. As Associate Director of the NIDDK funded Boston Nutrition Obesity Research Center (BNORC), we attend the biweekly BNORC Adipose and Metabolic Study Group Seminars. Additionally, as Co-Director of the Adipocyte Biology and Nutrient Metabolism Core at BNORC, our laboratory has the ability to characterize mouse metabolism and body composition, using a MRI to rapidly and noninvasively measure body fat and lean mass, metabolic chambers to measure energy expenditure, nutrient partitioning, and rates of spontaneous physical, and the hyperinsulinemic, euglycemic clamp technique to measure liver, adipose, and skeletal muscle insulin sensitivity in mouse models.

Staff
Andrew S. Greenberg, M.D., Laboratory Director
Senior Scientist, Director, Obesity and Metabolism Laboratory
Robert C and Veronica Atkins Professorship in Nutrition and Metabolism, Tufts University School of Medicine
Associate Professor, Friedman School of Nutritional Science and Policy
Physician, Department of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center
Research focus: Etiology of obesity and its complications; the role of inflammation in metabolic disorders and the regulation of adipocyte metabolism, inulin resistance, and diabetes

Qing-Wu Yan, Ph.D.
Scientist III
Research focus: Excess calorie-related metabolic complications – obesity, insulin resistance, type 2 diabetes

Thomas Bowman, Ph.D., Postdoctoral Fellow
Rajween Kaur, BA, Research Assistant
Kayleigh O’Keeffe, B.A., Research Technician
Elizabeth Killion, B.A., Predoctoral Student, Friedman School
John Griffin, B.A., Predoctoral Student, Friedman School
Chris Zymaris,
Budget and Administrative Assistant

For contact information, please click on the scientist’s webpage or visit the Tufts University online directory at http://whitepages.tufts.edu/.