Antioxidants

Mission
The Antioxidants Research Laboratory conducts preclinical and clinical studies on the biochemical basis and functional outcomes of antioxidant nutrients and related phytochemicals and functional foods to determine their role in health promotion and disease prevention during the aging process via modulation of oxidative stress, inflammation, glucoregulation, and microbiota.

Lab Objectives
Determine the bioavailability, pharmacokinetics, metabolism, and mechanisms of phytochemicals (e.g., carotenoids, phenolic acids, polyphenols) from fruit, nuts, vegetables, and whole grains using in vitro, animal model, and human studies.

Determine the effect of phytochemicals (e.g., alkylresorcinols, flavonoids) from fruit, nuts, vegetables, and whole grains on intermediary biomarkers of age-related conditions (e.g., cytokines, isoprostanes), metabolomics parameters (e.g., fatty acids, organic acids), physiological profiles (e.g., endothelial responses, glucose homeostasis), and functional outcomes relevant to cardiovascular disease, type 2 diabetes, and cognitive decline.

Determine the effect of phytochemicals (e.g., anthocyanins, proanthocyanidins) from fruit, nuts, vegetables, and whole grains on microbiota in the lower gut and physiological profiles (e.g., innate immunity) relevant to glucoregulation, inflammation, endothelial function, and oxidative stress.

VIDEO:Watch Dr. Blumberg describe his lab’s research
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Lab Members

Chung-Yen (Oliver) Chen, Ph.D., Interim Laboratory Director
Scientist I and Associate Professor, Nutrition Science and Policy
Research focus: Health benefits of phytochemicals and functional foods and beverages in metabolic disorders; pharmacokinetics of phytochemicals; Phase II enzyme mediated polyphenol metabolism; reciprocal interaction between polyphenols and microbiome

Jeffrey B. Blumberg, Ph.D., Senior Scientist
Senior Scientist and Professor, Nutrition Science and Policy
Research focus: food content, bioavailability, and pharmacokinetics of polyphenols and their impact on biomarkers of chronic disease risk

Elizabeth Johnson, Ph.D.
Scientist I and Associate Professor, Nutrition Science and Policy
Research focus: absorption and metabolism of carotenoids and their relationships with body composition, cognitive performance, and age-related eye disease prevention

Diane McKay, Ph.D.

Scientist III and Assistant Professor, Nutrition Science and Policy
Research focus: human studies of antioxidant-rich foods and beverages on metabolic and clinical outcomes


Jason Walsh, Ph.D., Sr. Research Assistant/Lab Manager
Jordan Haddock, M.S., Senior Research Technician
Sergio Costa, PhD, Visiting Scientist
Peng Du, PhD, Visiting Scientist
Ying Zhang, PhD, Visiting Scientist
Emily Mohn, M.S., Graduate Student
Kenneth Racicot, M.S., Graduate Student
Klinsmann Santos, M.S., Visiting Graduate Student
Aiguo Luo, M.S., Visiting Graduate Student

Christopher Pereira, Budget & Administrative Assistant

For contact information, please click on the scientist’s webpage or visit the Tufts University online directory at http://whitepages.tufts.edu/.