Antioxidants

Mission
The Antioxidants Research Laboratory conducts basic and clinical studies on the biochemical basis and functional outcomes of antioxidant nutrients and related phytochemicals to determine their role in health promotion and disease prevention during the aging process via modulation of oxidative stress, inflammation, and glucoregulation.

Lab Objectives
Determine the bioavailability, pharmacokinetics, metabolism, and mechanisms of phytochemicals (e.g., carotenoids, phenolic acids, polyphenols) from fruit, nuts, and whole grains using in vitro, animal model, and human studies

Determine the effect of phytochemicals (e.g., alkylresorcinols, flavonoids) from fruit, nuts, and whole grains on intermediary biomarkers of age-related conditions (e.g., cytokines, isoprostanes), metabolomics parameters (e.g., fatty acids, organic acids), physiological profiles (e.g., endothelial responses, glucose homeostasis), and functional outcomes relevant to cardiovascular disease and type 2 diabetes.

Determine the effect of phytochemicals (e.g., anthocyanins, proanthocyanidins) from fruit, nuts, and whole grains on intermediary biomarkers of age-related conditions (e.g., oxidatively modified DNA) and physiological profiles (e.g., innate immunity) relevant to cancer, particularly colorectal and liver cancers.

Staff
Jeffrey B. Blumberg, Ph.D., Laboratory Director
Senior Scientist and Professor, Nutrition Science and Policy
Research focus: food content, bioavailability, and pharmacokinetics of polyphenols and their impact on biomarkers of chronic disease risk

Chung-Yen (Oliver) Chen, Ph.D.
Scientist I and Assistant Professor, Nutrition Science and Policy
Research focus: molecular mechanisms of antioxidant action, health benefits of phytochemical-rich foods and beverages; polyphenol metabolism in the microbiome

Elizabeth Johnson, Ph.D.
Scientist I and Associate Professor, Nutrition
Research focus: absorption and metabolism of carotenoid; relationships with body composition and age-related eye disease prevention

Diane McKay, Ph.D.

Scientist II
Research focus: human studies of antioxidant-rich foods and beverages on metabolic and clinical outcomes

Rohini Vishwanathan, Ph.D.
Scientist III

Carly Zampariello, MS, Lab Manager
Daniel Polasky, BS, Research Technician
Alison Kamil, MS, Graduate Student
Kenneth Racicot, MS, Graduate Student
Jo Obelsky, Administrative Assistant

For contact information, please click on the scientist’s webpage or visit the Tufts University online directory at http://whitepages.tufts.edu/.