To study the role of B vitamins in health and age-related diseases at epidemiological, biochemical and molecular levels.
1. Develop new and efficient methods for assessing nutritional status in individuals for B vitamins and their functional markers with internal standards obtained from plants grown on D2O or yeast grown on C-13 glucose.
2. Determine the biochemical, pathological and functional impact of nutritional status and genetic variations in B complex vitamin metabolism with special emphasis on the effect of age, in human, animal and cell culture models. Consider the nutritional status of other B vitamins while studying the effect of each B vitamin.
3. Determine the impact of mandatory folic acid fortification of cereals including effects of improved nutritional status as well as excess intake of folic acid on outcomes including disease risk, cognitive function, inflammation and immune response, with emphasis on understanding the mechanism behind the side-effects.
Jacob Selhub, Ph.D., Laboratory Director
Research focus: Relationship between B vitamin nutriture, homocysteine, and vascular disease
Ligi Paul Pottenplackel, Ph.D.
Research focus: Vitamin B12 and folate metabolism, genetic and nutritional perturbations of these pathways and their effect on methylation reactions, gene expression and disease risk