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Cardiovascular disease (CVD) continues to be the leading cause of death in the United States and one in three adults live with one or more types of CVD – with risk increasing with age. HNRCA research teams study preventive measures, especially through food components, dietary patterns, genetic factors, biomarkers and mechanistic pathways as they impact cardiovascular health. The scope of this work ranges from in vitro experiments to human intervention studies.

Key research objectives
• Determine the effect of food components and their metabolites, dietary patterns, and lipid-modifying therapies on cardiometabolic risk factors and lipoprotein, sterol, bile acid, and fatty acid metabolism in humans, and using animal, and in vitro

• Identify novel biomarkers of food intake (e.g., metabolomic, lipidomic, proteomic, and microbiome) and relate them to cardiovascular health.

• To identify interactions between the genome, epigenome and diet and lifestyle that signify cardiovascular disease risk.

Scientists
Paul Jacques, D.Sc.
Stefania Lamon-Fava, M.D., Ph.D.
Chao-Qiang Lai, Ph.D.
Alice Lichtenstein, D.Sc.
Nirupa Matthan, Ph.D.
Nicola McKeown, Ph.D.
Jose Ordovas, Ph.D.
Laurence Parnell, Ph.D.
Kyla Shea, Ph.D.
Caren Smith, M.S., D.V.M.