Nutrition and Genomics

The Nutrition and Genomics Laboratory is a pioneer in the study of gene-diet interactions in the area of cardiovascular diseases, utilizing both genetic epidemiology approaches as well as controlled dietary intervention studies.

Lab Objectives
1. Identify metabolomic-based biomarkers of dietary and exercise behavior in normal-weight and obese elderly individuals and the genetic variants associating with the baseline levels of these metabolites.

2. Determine the demographic, behavioral, metabolomic and genetic drivers of the excess obesity in elderly population(s) suffering health disparity.

3. Determine the relationships between aging-related changes in gene expression, endogenous and exogenous microRNAs, metabolic factors and chronotype in response to metabolic challenges such as unhealthy dietary habits, high-fat loads and physical inactivity.

4. Identify genomic, and epigenomic and metabolic markers that predict cardiovascular status and metabolic health during aging and define specific dietary, physical activity and other lifestyle factors that are most suitable to an individual’s genetic and epigenetic profile.

5. Use a multi-omics approach to identify multi-level genome/metagenome/diet interactions that modulate inflammation and aging pathways in normal-weight and obese individuals.

Lab Members
Jose M. Ordovas, Ph.D., Laboratory Director
Senior Scientist and Professor, Nutrition and Molecular Genetics
Research focus: molecular biology, nutrition, and genetics; lipoproteins and cardiovascular disease risk

Kris Richardson, Ph.D.
Scientist III
Research Focus: Bioinformatics, gene by diet interaction analysis in obesity, SNP analysis and functional annotation, microRNAs, molecular biology

Caren E. Smith, M.S., D.V.M
Scientist II
Research focus: nutrient-gene interactions in cardiovascular disease, exercise-gene interactions in cardiovascular disease.

Martin S. Obin, Ph.D.
Adjunct Scientist
Research focus: Nutrient effects on obesity-associated complications and aging

Chao-Qiang Lai, Ph.D.
Research Molecular Biologist/Geneticist
Nutrition, genetics, and healthy aging; epigenomics, gene by diet interaction, risk prediction and prevention of cardiovascular and metabolic disease

Laurence D. Parnell, Ph.D.
Computational Biologist
Research focus: My research seeks to understand how the human genome and its numerous genetic polymorphisms interpret the lifestyle of the individual – diet and physical activity among others – in ways that affect risk of cardiovascular disease, type 2 diabetes, hypertension and obesity. This is done with computational tools and databases, with a goal of describing factors pertinent to personalized nutrition.

Yu-Chi Lee, M.S., PhD Student

Luke Baccari, Research Administrator
Kathy Li, Administrative Assistant

For contact information, please click on the scientist’s webpage or visit the Tufts University online directory at

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