Current Projects

  • Biochemical functions and regulations of beta-carotene 9’,10’-oxygenase (BCO2) cleavage enzyme on carotenoid (lycopene, beta-cryptoxanthin, lutein, and zeaxanthin) metabolism and their interaction with tobacco smoke and chronic alcohol consumption.
  • Biologic activity of carotenoid cleavage metabolites and their molecular mechanisms functioning as activators of nuclear receptors (PPARs, RXRs and RARs) and SIRT1.
  • Anti-inflammatory effect of tomato carotenoids and apolycopenoids against non-alcoholic steatohepatitis (NASH) and alcoholic steatohepatitis (ASH) and alcohol-promoted hepatic carcinogenesis in animal models and in human liver cancer cells.
  • Preventive effects of beta-cryptoxanthin against chronic obstructive pulmonary disease (COPD) and lung cancer in mouse models and ferret model.
  • Anti-inflammatory effects of lutein in dextran sulfate sodium-induced colitis and colon cancer in mouse model and in human colon cancer cells.
  • Modulation of molecular biomarkers by carotenoids in the human subjects (cigarette smokers, alcoholics and patients with ASH and NASH).