Xiang-Dong Wang, M.D., Ph.D.

Senior Scientist, Lab Director
Nutrition and Cancer Biology Laboratory
Phone: (617) 556-3130
Fax: (617) 556-3344
E-mail: xiang-dong.wang@tufts.edu




M.D., Medicine, Peking University
Ph.D., Nutrition, Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy at Tufts University

Research Focus
Mechanistically understand the cancer-promoting role of tobacco smoking, chronic alcohol intake, and high fat/sugar consumption; and 2) Molecular mechanisms underlying the anti-carcinogenic role of the bioactive components of fruits/vegetables and to develop the complementary dietary agents to prevent cancer development.

Academic Appointments
Professor, Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy at Tufts University

Selected Professional Affiliations
American Society of Nutrition
American Association for Cancer Research
International Carotenoid Society
International Society of Biomedical Research on Alcoholism
Associate Editor, Advances in Nutrition, American Society of Nutrition
Deputy Editor-in-Chief, Hepatobilinary Surgery and Nutrition

Select Publications|
Li X, Lian F, Liu C, Hu KQ, Wang X-D. Isocaloric pair-fed high-carbohydrate diet induced more hepatic steatosis and inflammation than high-fat diet mediated by miR-34a/SIRT1 axis in mice. Scientific Reports 5:16774. doi: 10.1038/srep16774, 2015

Stice CP, Liu C, Aizawa1 K, Greenberg AS, Ausman LM, and Wang X-D. Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p4502E1 induction in rodent models. Arch Biochem Biophys 572:81-88, 2015

Ip BC, Liu C, Lichtenstein AH, von Lintig J and Wang X-D. Lycopene and apo-10’-lycopenoic acid have differential mechanism of protection against hepatic steatosis in beta-carotene-9’,10’-oxygenase knockout male mice. J Nutr 145:268-76, 2015

Li X, Liu C, Ip BC, Hu KQ, Smith DE, Greenberg AS, Wang X-D. Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in Mice. Journal of Experimental & Clinical Cancer Research 34, 138-144, 2015

Aizawa K, Liu C, Veeramachaneni S, Hu KQ, Smith DE, Wang X-D. Tobacco carcinogen (NNK) induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation. International Journal of Cancer 139:1171-1181, 2016.

All Publications (Pub Med)