Joel B. Mason, M.D.

Senior Scientist and Laboratory Director
Vitamins and Carcinogenesis Laboratory
Director, HNRCA Cancer Cluster
Professor of Medicine and Nutrition
Phone: (617) 556-3194
Fax: (617) 556-3234


M.D., University of Chicago, Pritzker School of Medicine

Research Focus
1-Carbon nutrients: modulation of carcinogenesis
Obesity: modulation of carcinogenesis
Colonic microbiome and carcinogenesis

Academic Appointments
Professor of Medicine and Nutrition , Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy at Tufts University

Selected Professional Affiliations
Staff Gastroenterologist, Tufts Medical Center
Fellow, American Gastroenterological Association
Member, American Association for Cancer Research
Member, American Society for Nutrition
Member, American College of Physicians

Select Publications
Liu Z, Brooks RS, Ciappio ED, Kim SJ, Crott JW, Bennett G, Greenberg AS, Mason JB. Diet-induced obesity elevates colonic TNF-alpha in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer. J Nutr Biochem. 2012 Oct;23(10):1207-13.

Ciappio ED, Liu Z, Brooks RS, Mason JB, Bronson RT, Crott JW. Maternal B vitamin supplementation from preconception through weaning suppresses intestinal tumorigenesis in Apc1638N mouse offspring. Gut. 2011 Dec;60(12):1695-702.

Tao MH, Mason JB, Marian C, McCann SE, Platek ME, Millen A, Ambrosone C, Edge SB, Krishnan SS, Trevisan M, Shields PG, Freudenheim JL.Promoter methylation of E-cadherin, p16, and RAR-beta(2) genes in breast tumors and dietary intake of nutrients important in one-carbon metabolism. Nutr Cancer. 2011 Oct;63(7):1143-50

Liu Z, Ciappio ED, Crott JW, Brooks RS, Nesvet J, Smith DE, Choi SW, Mason JB. Combined inadequacies of multiple B vitamins amplify colonic Wnt signaling and promote intestinal tumorigenesis in BAT-LacZxApc1638N mice. FASEB J. 2011 Sep;25(9):3136-45.

Protiva P, Mason JB, Liu Z, Hopkins ME, Nelson C, Marshall JR, Lambrecht RW, Pendyala S, Kopelovich L, Kim M, Kleinstein SH, Laird PW, Lipkin M, Holt PR. Altered folate availability modifies the molecular environment of the human colorectum: implications for colorectal carcinogenesis. Cancer Prev Res (Phila). 2011 Apr;4(4):530-43.

All Publications (Pub Med)